gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Etentamig binds CD3 on T cells and BCMA on myeloma cells, redirecting T-cell cytotoxicity (perforin/granzyme) to kill BCMA+ tumor cells; CD3+ T cells are activated, not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
low-activating CD3 arm
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06158841
disease_id_num_tar_ref
2257
drug_id_num_tar_ref
6034