gene_symbol
CASP9
hgnc_id
HGNC:1511
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
iC9 is a suicide switch within the engineered CAR-T cells; when activated by a small-molecule dimerizer (e.g., rimiducid), it dimerizes caspase-9 and triggers apoptosis of the CAR-T cells themselves. The CAR-T does not recognize iC9 on target cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Safety switch within CAR-T cells; activatable by rimiducid to ablate the cells in case of severe toxicity
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06305299
disease_id_num_tar_ref
2266
drug_id_num_tar_ref
6060