gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
BCMA-specific CAR T cells bind BCMA on target cells, form an immune synapse, and kill via perforin/granzyme release and death-receptor (e.g., Fas/FasL) signaling, leading to apoptosis/lysis of BCMA+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane BCMA on malignant plasma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05308875
disease_id_num_tar_ref
2268
drug_id_num_tar_ref
6069