gene_symbol
ROR1
hgnc_id
HGNC:10256
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
An anti-ROR1 antibody–drug conjugate binds ROR1, is internalized, and releases MMAE intracellularly, inhibiting microtubule polymerization and causing mitotic arrest and apoptosis of ROR1-expressing cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface tumor-associated antigen targeted by the antibody moiety
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06395103
disease_id_num_tar_ref
2281
drug_id_num_tar_ref
6107