gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR binding to BCMA activates the engineered T cells (CD3ΞΆ/costimulatory signaling), leading to perforin/granzyme-mediated cytolysis of BCMA-positive cells (and potentially Fas/FasL apoptosis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05712083
disease_id_num_tar_ref
2284
drug_id_num_tar_ref
6110