gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on target cells and engages Fc receptors on immune effectors to induce ADCC (and possibly CDC), killing EGFR+ cells; it also blocks EGFR signaling (antiproliferative).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain to block ligand binding and receptor dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06585488
disease_id_num_tar_ref
2301
drug_id_num_tar_ref
6153