gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-expressing NK cells bind BCMA on target cells, triggering NK activation and degranulation (perforin/granzyme) and cytokine-mediated killing, leading to direct lysis/apoptosis of BCMA+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane-bound BCMA on malignant plasma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06242249
disease_id_num_tar_ref
2304
drug_id_num_tar_ref
6157