gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2 on target cells and engages Fcγ receptors on NK cells/macrophages to trigger ADCC (and phagocytosis); also blocks HER2 dimerization/signaling, leading to growth arrest and apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular subdomain II (dimerization/docking interface)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05825781
disease_id_num_tar_ref
2306
drug_id_num_tar_ref
6168