gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Pertuzumab opsonizes HER2+ tumor cells and engages CD16A on NK cells via its Fc to trigger ADCC, killing HER2-expressing targets, not the CD16A-expressing effector cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated engagement for ADCC; affinity influenced by FCGR3A V158F polymorphism
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05825781
disease_id_num_tar_ref
2306
drug_id_num_tar_ref
6168