gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2 on target cells, is internalized, and releases a camptothecin-derived topoisomerase I inhibitor that induces DNA damage leading to cell death; its Fc can also trigger ADCC against HER2+ cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface receptor targeted by ADC antibody; may engage ADCC via Fc
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06445400
disease_id_num_tar_ref
2307
drug_id_num_tar_ref
6169