gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Pertuzumab (IgG1) binds HER2 on target cells and engages FcγR-expressing immune effectors (e.g., NK cells) to mediate ADCC, killing HER2+ cells; HER2 signaling blockade can also promote apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain subdomain II (dimerization interface)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06445400
disease_id_num_tar_ref
2307
drug_id_num_tar_ref
6170