gene_symbol
TNFRSF13C
hgnc_id
HGNC:17755
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Afucosylated IgG1 binds BAFF-R on B cells and engages Fcγ receptors on NK cells/macrophages to induce ADCC/ADCP, depleting BAFF-R+ cells; BAFF signaling blockade may also promote apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor on B cells; binding blocks BAFF/BLyS signaling and enables ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06293365
disease_id_num_tar_ref
2314
drug_id_num_tar_ref
6181