gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
By binding CD38 on target cells, the antibody engages Fc effector functions to trigger NK cell–mediated ADCC, complement-dependent cytotoxicity (CDC), and antibody-dependent phagocytosis; CD47 blockade further enhances macrophage phagocytosis of CD38+ cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ecto-enzyme (NADase/cyclase) on malignant plasma/B cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05293912
disease_id_num_tar_ref
2316
drug_id_num_tar_ref
6183