gene_symbol
CTLA4
hgnc_id
HGNC:2505
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CTLA-4 IgG1 binds CTLA-4 on T cells (notably Tregs) and its Fc engages FcγR-expressing effectors to mediate ADCC/ADCP, depleting CTLA-4+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Immune checkpoint receptor on T cells; Fc-engineered IgG1 mediates Treg depletion via Fc effector engagement
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06251973
disease_id_num_tar_ref
2321
drug_id_num_tar_ref
6192