gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds HER2 on target cells and engages Fcγ receptor–bearing effector cells via its IgG1 Fc to trigger antibody‑dependent cellular cytotoxicity (ADCC), killing HER2+ cells; also inhibits HER2 signaling, which can promote apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain II (dimerization interface) to block HER2 dimerization, especially HER2:HER3; mediates ADCC via Fcγ receptors on effector cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06835348
disease_id_num_tar_ref
2331
drug_id_num_tar_ref
6216