gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds TROP-2, is internalized, and releases SN-38; SN-38 inhibits DNA topoisomerase I, stabilizing Topo I–DNA complexes and causing DNA damage, replication stress, and apoptosis (including bystander killing).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC payload (SN-38) target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05838521
disease_id_num_tar_ref
2335
drug_id_num_tar_ref
6228