gene_symbol
CTLA4
hgnc_id
HGNC:2505
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 Fc effector functions recruit FcγR+ cells (NK cells/macrophages) to mediate ADCC/ADCP (± CDC), selectively depleting CTLA-4–high intratumoral Tregs; CTLA-4 blockade itself is non-cytotoxic.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
pH-sensitive binding; preserves CTLA-4 recycling; retains Fc effector function
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05671510
disease_id_num_tar_ref
2343
drug_id_num_tar_ref
6246