gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 on tumor cells and engages Fcγ receptor–bearing immune cells (e.g., NK cells, macrophages) to mediate antibody‑dependent cellular cytotoxicity; it also inhibits HER2 signaling, promoting apoptosis.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (subdomain IV) of HER2; induces ADCC via Fc engagement
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05760612
disease_id_num_tar_ref
2356
drug_id_num_tar_ref
6274