gene_symbol
IGHG1
hgnc_id
HGNC:5525
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
FT825 does not target cells for expressing an IgG1 Fc region. Its engineered CD16a binds the Fc of a therapeutic antibody that is bound to a tumor antigen, bridging and activating the T cell to kill the antibody-opsonized, antigen-positive cells via T‑cell cytotoxicity (perforin/granzyme).
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Engagement via high-affinity non-cleavable CD16a (FCGR3A); enables ADCC when a therapeutic IgG1 antibody is present
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06241456
disease_id_num_tar_ref
2372
drug_id_num_tar_ref
6318