gene_symbol
TGFB2
hgnc_id
HGNC:11768
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
FT825 kills HER2+ cells via CAR T-cell cytotoxicity (perforin/granzyme) and can mediate ADCC via CD16a with a compatible antibody. The TGF-β signal‑redirection receptor only modulates T-cell signaling in response to TGF‑β2; it does not target TGF‑β2–expressing cells for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binding via TGFβ signal-redirection receptor (TGFβ-SRR)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06241456
disease_id_num_tar_ref
2372
drug_id_num_tar_ref
6318