gene_symbol
TGFB3
hgnc_id
HGNC:11769
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
FT825 kills HER2-expressing cells via CAR-mediated T-cell cytotoxicity. TGF-beta 3 only engages the engineered TGF-beta signal-redirection receptor to enhance activation and resistance to suppression; it is not a killing target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binding via TGFβ signal-redirection receptor (TGFβ-SRR)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06241456
disease_id_num_tar_ref
2372
drug_id_num_tar_ref
6318