gene_symbol
CXCL8
hgnc_id
HGNC:6025
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
IL-8 is not a killing target. CXCR2 on FT825 uses IL-8 as a chemotactic cue to enhance trafficking; cytotoxicity occurs when the CAR T cells recognize HER2 (or via CD16a-mediated ADCC with a therapeutic antibody), not by binding IL-8.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Trafficking via CXCR2 chemokine receptor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06241456
disease_id_num_tar_ref
2372
drug_id_num_tar_ref
6318