gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 Fc engages FcγR-bearing immune cells (e.g., NK cells) to mediate ADCC, with some complement-dependent cytotoxicity; EGFR blockade is antiproliferative but cytolysis occurs via ADCC/CDC against EGFR-expressing cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain; blocks ligand binding and receptor dimerization; induces ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06241456
disease_id_num_tar_ref
2372
drug_id_num_tar_ref
6324