gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds CD19 and is internalized; the released PBD payload crosslinks DNA at N2-guanine in the minor groove, causing DNA damage, cell-cycle arrest, and apoptosis. Killing is determined by CD19-mediated delivery, not by the DNA target itself.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tesirine (PBD dimer) forms DNA interstrand crosslinks in the minor groove.
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05453396
disease_id_num_tar_ref
2373
drug_id_num_tar_ref
6325