gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on target cells and its IgG1 Fc engages Fcγ receptors on effector cells (e.g., NK cells), inducing antibody-dependent cellular cytotoxicity (perforin/granzyme lysis; may also contribute via ADCP/CDC).
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain III) to block ligand binding and receptor dimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06046482
disease_id_num_tar_ref
2377
drug_id_num_tar_ref
6336