gene_symbol
ROR1
hgnc_id
HGNC:10256
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Tri-specific T‑cell engager binds ROR1 on tumor cells and CD3 on T cells, forming an immune synapse that activates CTLs to kill ROR1+ cells via perforin/granzyme-mediated apoptosis; HSA binding only extends half-life.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor tyrosine kinase-like orphan receptor 1 on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06299163
disease_id_num_tar_ref
2396
drug_id_num_tar_ref
6387