gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD3+ T cells are not killed; the drug bridges CD3 on T cells to ROR1 on tumor cells, activating T-cell cytotoxicity (perforin/granzyme) against ROR1+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor complex component; epsilon chain commonly targeted by T-cell engagers
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06299163
disease_id_num_tar_ref
2396
drug_id_num_tar_ref
6387