gene_symbol
FCGR3B
hgnc_id
HGNC:3620
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells; its Fc engages Fcγ receptors (including CD16b) on effector cells to trigger ADCC/ADCP and complement-mediated killing of CD20+ B cells. CD16b+ cells are effectors, not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-FcγRIIIb engagement on neutrophils; affinity enhanced by afucosylated Fc
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05650723
disease_id_num_tar_ref
2397
drug_id_num_tar_ref
6390