gene_symbol
CLEC12A
hgnc_id
HGNC:31713
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells recognize CLEC12A on AML cells and induce T-cell cytotoxicity, primarily via perforin/granzyme-mediated apoptosis and Fas/FasL signaling; IL-18 enhances CAR T activity and can recruit innate effectors.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Myeloid surface antigen on AML blasts and leukemic stem cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06017258
disease_id_num_tar_ref
2404
drug_id_num_tar_ref
6415