gene_symbol
IL18R1
hgnc_id
HGNC:5988
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CAR T cells recognize and kill CLEC12A+ AML cells via CAR-mediated cytolysis. The IL-18 secreted by the CAR T cells signals through IL18R1 on immune cells to enhance activation but does not target IL18R1+ cells for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Alpha chain of IL-18 receptor heterodimer engaged by secreted IL-18
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06017258
disease_id_num_tar_ref
2404
drug_id_num_tar_ref
6415