gene_symbol
IL18RAP
hgnc_id
HGNC:5989
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CAR T cells kill CLEC12A (CD371)-positive AML cells. IL-18 secretion signals via IL18RAP to activate immune cells, but IL18RAP-expressing cells are not targeted or killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Accessory chain of IL-18 receptor heterodimer engaged by secreted IL-18
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06017258
disease_id_num_tar_ref
2404
drug_id_num_tar_ref
6415