gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR on tumor cells; its Fc engages CD16a on NK cells to trigger ADCC, leading NK cells to kill EGFR+ targets. CD16a-expressing cells are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated engagement on NK cells to trigger ADCC; affinity influenced by FCGR3A V158F polymorphism
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06306846
disease_id_num_tar_ref
2412
drug_id_num_tar_ref
6439