gene_symbol
BTN3A1
hgnc_id
HGNC:1138
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Allogeneic Vγ9Vδ2 T cells recognize phosphoantigen-induced BTN3A1/BTN2A1 complexes on target cells via their TCR and directly lyse them through perforin/granzyme release (with supportive cytokine-mediated cytotoxicity).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Phosphoantigen-dependent recognition via Vγ9Vδ2 TCR; cooperates with BTN2A1
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05755854
disease_id_num_tar_ref
2418
drug_id_num_tar_ref
6455