gene_symbol
BTN2A1
hgnc_id
HGNC:1136
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Vγ9Vδ2 T cells engage the BTN3A1/BTN2A1 complex induced by phosphoantigens on target cells, activating HLA‑independent cytotoxicity and killing via perforin/granzyme (and death‑receptor) pathways.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Works with BTN3A1 to enable Vγ9Vδ2 TCR recognition of phosphoantigen-stressed cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05755854
disease_id_num_tar_ref
2418
drug_id_num_tar_ref
6455