gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The drug binds CD3 epsilon on T cells to activate and redirect them; these T cells then kill BCMA-expressing myeloma cells via cytolytic synapses (perforin/granzyme). CD3+ T cells are not the targets killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
TCR-CD3 complex component
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06669247
disease_id_num_tar_ref
2430
drug_id_num_tar_ref
6491