gene_symbol
GPC3
hgnc_id
HGNC:4451
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The Ac-225–labeled GPC3-targeted radioligand binds GPC3 and emits short-range alpha particles that induce clustered DNA double-strand breaks in GPC3-positive cells, causing irreversible damage and cell death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface heparan sulfate proteoglycan; Wnt co-receptor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06726161
disease_id_num_tar_ref
2436
drug_id_num_tar_ref
6509