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gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
By binding CD3 on T cells and CD19 on target cells, it crosslinks and activates T cells (augmented by 4-1BB costimulation and PD-L1 blockade) to kill CD19+ cells via perforin/granzyme-mediated cytotoxicity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
trial_id_tar_ref
drug_id_tar_ref
nct_id_tar_ref
NCT05485753
disease_id_num_tar_ref
2437
drug_id_num_tar_ref
6510