gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD3 is an engager on T cells. GNC-038 binds CD3 to recruit and activate T cells, which then kill CD19+ tumor cells (with 4-1BB costimulation and PD-L1 blockade). CD3+ T cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Targeting the CD3 complex on T cells; epitope typically on CD3 epsilon subunit
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05485753
disease_id_num_tar_ref
2437
drug_id_num_tar_ref
6510