gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Bispecific anti-EGFR/CD3 T-cell engager crosslinks T cells to EGFR+ cells, activating cytotoxic T lymphocytes to kill target cells via perforin/granzyme-mediated lysis (and related T-cell cytotoxic pathways).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor tyrosine kinase; bispecific T-cell engager target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06208033
disease_id_num_tar_ref
226
drug_id_num_tar_ref
639