gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The antibody binds Claudin 18.2 on tumor cells and recruits immune effectors to kill via FcγR-mediated ADCC, complement-dependent cytotoxicity (CDC/MAC), and antibody-dependent cellular phagocytosis (ADCP).
enzyme_product
Off
epitope
On
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
isoform 2 of Claudin-18 expressed on gastric/GEJ tumor cell membranes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06767449
disease_id_num_tar_ref
2442
drug_id_num_tar_ref
6530