gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The antibody binds CLDN18.2 on tumor cells; its Fc engages CD16A on NK cells to trigger ADCC (and can also enable CDC/ADCP), killing CLDN18.2-positive tumor cells, not CD16A-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-dependent engagement mediating NK cell ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06767449
disease_id_num_tar_ref
2442
drug_id_num_tar_ref
6530