gene_symbol
C1QA
hgnc_id
HGNC:1241
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Zolbetuximab binds Claudin 18.2 on tumor cells and triggers ADCC, CDC (via C1q binding to Fc), and ADCP to kill CLDN18.2+ cells. C1q is part of complement activation but is not the antigen targeted; cells expressing C1q are not directly killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds IgG1 Fc to initiate complement-dependent cytotoxicity (CDC); represents the C1q complex (C1QA/B/C)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06767449
disease_id_num_tar_ref
2442
drug_id_num_tar_ref
6530