gene_symbol
IL3RA
hgnc_id
HGNC:6012
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells recognize CD123 (often with TIM-3) via the dual CAR, triggering T-cell activation and perforin/granzyme-mediated lysis of CD123+ target cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Dual-target CAR context; cell-surface receptor on AML blasts/LSCs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06125652
disease_id_num_tar_ref
2443
drug_id_num_tar_ref
6531