gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
SMET12 engages CD3 on T cells and EGFR on tumor cells to activate T-cell cytotoxicity (perforin/granzyme) against EGFR-expressing tumor cells; CD3ε-expressing T cells are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell surface CD3 complex subunit; bispecific T-cell engager target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06208033
disease_id_num_tar_ref
226
drug_id_num_tar_ref
639