gene_symbol
TNFRSF4
hgnc_id
HGNC:11918
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The afucosylated IgG1 antibody binds OX40 on activated T cells and engages FcγRIIIa on NK cells/other effectors to trigger ADCC, leading to lysis/apoptosis of OX40+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface costimulatory receptor; TNF receptor superfamily member
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06376045
disease_id_num_tar_ref
2449
drug_id_num_tar_ref
6546