gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Native TCRs on infused TILs recognize the patient-specific peptide–HLA class I complex and induce target-cell death via cytotoxic granule release (perforin/granzyme–mediated apoptosis), with possible Fas/FasL signaling.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
CD8+ TIL; MHC class I–restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05724732
disease_id_num_tar_ref
2450
drug_id_num_tar_ref
6547