gene_symbol
IL5RA
hgnc_id
HGNC:6017
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Benralizumab binds IL-5Rα on target cells and engages FcγRIIIa on NK cells, triggering potent ADCC (and related effector functions), leading to apoptosis/depletion of IL-5Rα-expressing eosinophils and basophils.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor subunit on eosinophils/basophils; blocks IL-5 signaling and flags cells for ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05966584
disease_id_num_tar_ref
2452
drug_id_num_tar_ref
6553