gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Benralizumab uses its afucosylated Fc to engage FcγRIIIa (CD16a) on NK cells and trigger ADCC against IL-5Rα–expressing eosinophils/basophils; CD16a-expressing cells are effectors, not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated effector engagement; afucosylated IgG1 Fc increases affinity to drive ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05966584
disease_id_num_tar_ref
2452
drug_id_num_tar_ref
6553