gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
HLA-A*02 engagement of the Tmod inhibitory receptor prevents CAR T activation; cytotoxicity is directed only to mesothelin-positive cells lacking HLA-A*02 via T-cell perforin/granzyme pathways.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
On
other_modifier
LIR-1–based inhibitory receptor (Tmod blocker)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06051695
disease_id_num_tar_ref
2453
drug_id_num_tar_ref
6557