gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Native TCRs on infused neoantigen‑reactive T cells recognize the neoantigen–HLA class II complex and directly lyse target cells via perforin/granzyme (± Fas–FasL) pathways, with supportive IFN-γ effects.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
CD4+ TCR recognition; MHC II–restricted peptide-MHC complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06432075
disease_id_num_tar_ref
2456
drug_id_num_tar_ref
6562